货号	规格	价格	上海	北京	珠海	重庆	武汉
S80132-2mg买3赠1	99.40%	￥125.00 S80132-2mg ￥125.00 现货（买3赠1）	5 5	-	-	-	-
S80132-5mg买3赠1	99.40%	￥170.00 S80132-5mg ￥170.00 现货（买3赠1）	6 6	-	-	-	-
S80132-10mg买3赠1	99.40%	￥250.00 S80132-10mg ￥250.00 现货（买3赠1）	5 5	-	-	-	-
S80132-25mg买3赠1	99.40%	￥470.00 S80132-25mg ￥470.00 现货（买3赠1）	6 0 6	-	-	-	-
S80132-50mg促销	≥99%	￥1050.00 ￥840.00 S80132-50mg ￥840.00 2-3天	0 货期：2-3天	-	-	-	-
S80132-100mg	≥99%	￥1280.00 S80132-100mg ￥1280.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research

靶点：

Human mGlu4:240 nM (EC50);Rat mGlu4:110 nM (EC50);GluR

体内研究：

VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg)

参考文献：

1. Engers DW, et al. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009 Jul 23;52(14):4115-8. 2. Engers DW, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. J Med Ch 3. Jantas D, et al. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. Neurochem Int. 2015 Sep;88:124

溶解性：

DMSO : 100 mg/mL (380.68 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.807 ml	19.034 ml	38.068 ml
5 mM	0.761 ml	3.807 ml	7.614 ml
10 mM	0.381 ml	1.903 ml	3.807 ml
50 mM	0.076 ml	0.381 ml	0.761 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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VU 0361737