货号	规格	价格	上海	北京	武汉	南京
S80142-5mg	99.8%	￥320.00 S80142-5mg ￥320.00 现货	5 5	-	-	-
S80142-10mg	99.8%	￥560.00 S80142-10mg ￥560.00 现货	3 3	-	-	-
S80142-25mg	99.8%	￥1280.00 S80142-25mg ￥1280.00 现货	4 4	-	-	-
S80142-50mg	≥99%	￥1760.00 S80142-50mg ￥1760.00 2-3天	0 货期：2-3天	-	-	-
S80142-100mg	≥99%	￥3200.00 S80142-100mg ￥3200.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.

产品描述：

NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.

靶点：

Ras;Apoptosis;Apoptosis;Rho;Ras

体内研究：

NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice

参考文献：

1. Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39(2):760-7. 2. Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415 3. Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972 4. Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173(5):937-50

溶解性：

DMSO : 33.33 mg/mL (62.77 mM; Need ultrasonic) H2O : ≥ 32 mg/mL (60.27 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.883 ml	9.417 ml	18.834 ml
5 mM	0.377 ml	1.883 ml	3.767 ml
10 mM	0.188 ml	0.942 ml	1.883 ml
50 mM	0.038 ml	0.188 ml	0.377 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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