货号	规格	价格	上海	北京	珠海	重庆	武汉
S80152-5mg买3赠1	99.80%	￥96.00 S80152-5mg ￥96.00 现货（买3赠1）	5 5	-	-	-	-
S80152-10mg买3赠1	99.80%	￥140.00 S80152-10mg ￥140.00 现货（买3赠1）	6 6	-	-	-	-
S80152-25mg买3赠1	99.80%	￥220.00 S80152-25mg ￥220.00 现货（买3赠1）	5 5	-	-	-	-
S80152-50mg买3赠1	99.80%	￥330.00 S80152-50mg ￥330.00 现货（买3赠1）	4 4	-	-	-	-
S80152-100mg买3赠1	99.80%	￥490.00 S80152-100mg ￥490.00 现货（买3赠1）	2 0 2	-	-	-	-

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产品描述：

Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively

靶点：

BRafV600E:0.6 nM (IC50);CRAF:5 nM (IC50);Raf

体内研究：

Dabrafenib-treated females have mostly immature reproductive tracts with no evidence of ovulation, similar to age-matched controls; however, DAB-treated females have keratinized and histologically open vaginas

参考文献：

1. Greger JG, et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther, 2012, 11(4), 909-920. 2. Lee S, et al. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016 Jul 22. 3. Jung B, et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9. 4. Alexander M Menzies, et al. Dabrafenib and its potential for the treatment of metastatic melanoma. Drug Des Devel Ther. 2012; 6: 391–405. 5. Posobiec LM, et al. Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation. Birth Defects Res B Dev Reprod Toxicol. 2015 Dec;104(6):244-52.

溶解性：

DMSO : ≥ 33 mg/mL (63.52 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.925 ml	9.624 ml	19.247 ml
5 mM	0.385 ml	1.925 ml	3.849 ml
10 mM	0.192 ml	0.962 ml	1.925 ml
50 mM	0.038 ml	0.192 ml	0.385 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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Dabrafenib (GSK2118436)