| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80165-2mg买3赠1 |
99.30% | ￥50.00 |
>10 | - | - | - | - |
|
S80165-5mg买3赠1 |
99.30% | ￥75.00 |
>10 | - | - | - | - |
|
S80165-10mg买3赠1 |
99.30% | ￥125.00 |
>10 | - | - | - | - |
|
S80165-25mg买3赠1 |
99.30% | ￥260.00 |
4 | - | - | - | - |
|
S80165-50mg买3赠1 |
99.30% | ￥420.00 |
5 | - | - | - | - |
|
S80165-100mg买3赠1 |
99.30% | ￥600.00 |
3 | - | - | - | - |
|
| 产品描述： | Filgotinib (GLPG0634) is a selective and orally active JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively | ||||||||||||||||||||
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| 靶点： | JAK1:10 nM (IC50);JAK2:28 nM (IC50);Tyk2:116 nM (IC50);JAK3:810 nM (IC50);TyrosineKinases;JAK | ||||||||||||||||||||
| 体外研究： | Filgotinib (GLPG0634) dose-dependently inhibits the differentiation of Th2 cells mediated by IL-4, a cytokine that signals through JAK1 and JAK3. Filgotinib also inhibits Th1 differentiation with similar potencies of 1 μM or lower. Filgotinib (GLPG0634) does not inhibit JAK2 homodimer-mediated signaling induced by EPO or PRL (IC50 > 10 μM) | ||||||||||||||||||||
| 体内研究： | Filgotinib (GLPG0634; 3, 10, 30 mg/kg, p.o.) dose-dependently prevents disease progression in the therapeutic rat CIA model. Filgotinib (50 mg/kg, o.p.) protects bone and cartilage from degradation, effectively reduces infiltration of T cells (CD3+ cells) and macrophages (F4/80+ cells) in the paw, and decreases the serum levels of all cytokines and chemokines measured, including IL-6, IP-10, XCL1, and MCP-1. Filgotinib (GLPG0634; 0.1 and 0.3 mg/kg) shows efficacy in the rat CIA model | ||||||||||||||||||||
| 参考文献： | 1. Van Rompaey L, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013, 191(7), 3568-3577. 2. Menet CJ, et al. Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634. J Med Chem. 2014 Nov 17. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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