| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80166-5mg买3赠1 |
≥99% | ￥400.00 |
货期：2-3天 | - | - | - | - |
|
S80166-10mg买3赠1 |
99.00% | ￥650.00 |
7 | - | - | - | - |
|
S80166-25mg买3赠1 |
≥99% | ￥1200.00 |
货期：2-3天 | - | - | - | - |
|
S80166-50mg |
≥99% | ￥1600.00 |
货期：2-3天 | - | - | - | - |
|
S80166-100mg |
≥99% | ￥2100.00 |
货期：2-3天 | - | - | - | - |
|
S80166-200mg |
≥99% | ￥4000.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 27 nM (ALK1), 107.9 nM (ALK2), <5 nM (ALK3), 47.6 nM (ALK6);ALK;Autophagy;TGF-beta/Smad | ||||||||||||||||||||
| 体内研究： | DMH1 (5 mg/kg, i.p.) treatment significantly reduces the tumor growth in human lung cancer xenograft model | ||||||||||||||||||||
| 参考文献： | 1. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of mL347 as an ALK2 versus ALK 2. Sheng Y, et al. DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy. Acta Pharm Sin B. 2015 Jul;5(4):330-6. 3. Neely MD, et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci. 2012 Jun 20;3(6):482-91. 4. Hover LD, et al. Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. Cancer Lett. 2015 Nov 1;368(1):79-87. 5. Hao J, et al. DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer. PLoS One. 2014 Mar 6;9(6):e90748. | ||||||||||||||||||||
| 溶解性： | DMSO : 11.5 mg/mL (30.23 mM; Need ultrasonic and warming) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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