| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80170-1mg促销 |
98.70% | ￥232.00 ￥185.00 |
3 | - | - | - | - |
|
S80170-2mg促销 |
98.70% | ￥416.00 ￥332.00 |
8 | - | - | - | - |
|
S80170-5mg促销 |
98.70% | ￥640.00 ￥512.00 |
8 | - | - | - | - |
|
S80170-10mg促销 |
98.70% | ￥960.00 ￥768.00 |
7 | - | - | - | - |
|
S80170-25mg促销 |
98.70% | ￥1920.00 ￥1536.00 |
6 | - | - | - | - |
|
S80170-50mg促销 |
98.70% | ￥3360.00 ￥2688.00 |
5 | - | - | - | - |
|
S80170-100mg促销 |
98.70% | ￥4480.00 ￥3584.00 |
2 | - | - | - | - |
|
| 产品描述： | N6022(IC50 of 8 nM) is an effective, reversible, and selective S-Nitrosoglutathione reductase(GSNOR) inhibitor. | ||||||||||||||||||||
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| 靶点： | GSNOR | ||||||||||||||||||||
| 体外研究： | N6022 binds to rat plasma proteins in a concentration-dependent manner. At lower drug concentrations (20 μM), N6022 show more effect on ATP than on GSH. N6022 (IC50 of 8 nM and a Ki of 2.5 nM) binds in the GSNO substrate binding pocket like a competitive inhibitor. N6022 is uncompetitive with cofactors NAD+ and NADH. | ||||||||||||||||||||
| 体内研究： | N6022 treats rats in 50 mg/kg leading to a slight increase in the incidence of granulomas. In serum, N6022 remained in solution is up to 5 mg/mL. | ||||||||||||||||||||
| 细胞实验： | N6022 is dissolved in 5% DMSO. N6022 is tested using a rat hepatoma (H4IIE) cell line whereby cells are seeded into 96-well plates and cultured in medium containing 20% bovine serum. Following an equilibration period of 48 h, the cells are treated with N6022 (5% DMSO vehicle) at concentrations of 0, 1, 5, 10, 20, 50, 100, and 300 μM for 24 h at 37°C in 5% CO2. Camptothecin and rotenone are included as positive controls. The cell supernatant or the cells themselves are harvested for biochemical analysis. | ||||||||||||||||||||
| 参考文献： | 1. Green LS, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012, 51(10), 2157-2168 2. Sun X, et al. Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases. ACS Med Chem Lett. 2011, 2(5), 402-406. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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