| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80184-5mg买3赠1 |
99.20% | ￥150.00 |
5 | - | - | - | - |
|
S80184-10mg买3赠1 |
99.20% | ￥260.00 |
6 | - | - | - | - |
|
S80184-25mg促销 |
99.20% | ￥450.00 ￥360.00 |
6 | - | - | - | - |
|
S80184-50mg促销 |
99.20% | ￥780.00 ￥624.00 |
5 | - | - | - | - |
|
S80184-100mg促销 |
99.20% | ￥1310.00 ￥1040.00 |
4 | - | - | - | - |
|
S80184-200mg促销 |
≥98% | ￥2150.00 ￥1720.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons. | ||||||||||||||||||||
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| 靶点： | PI3Kγ:30 nM (IC50, Neurons);Apoptosis;PI3K | ||||||||||||||||||||
| 体内研究： | Administration of CAY10505 (0.6 mg/kg, p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly increases serum nitrite and (or) nitrate concentrations in hypertensive rats. Acetylcholine (ACh) and Sodium nitroprusside (SNP) produce endothelium-dependent and-independent relaxation in isolated rat aortic ring precontracted with Phenylephrine (3 μM), in a dose dependent manner. Administration of CAY10505 (0.6 mg/kg,p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly prevents hypertension-induced attenuation of ACh-induced endothelium-dependent relaxation. Deoxycorticosterone acetate salt (DOCA, 40 mg/kg, s.c.) induced hypertension markedly attenuates acetylcholine-induced endothelium-dependent relaxation, but does not affect SNP-induced endotheliumindependent relaxation | ||||||||||||||||||||
| 参考文献： | 1. Sun YY, Lin SH et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. 2013 Jul 19;8(7):e69019. 2. Tyagi S. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul, 90(7), 881-5. 3. Hofmann C, et al. PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform. Br J Haematol. 2014 Aug;166(4):529-39. 4. Jingyi Wang, et al. MiR-1976 Knockdown Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties Inducing Triple-Negative Breast Cancer Metastasis. Cell Death Dis. 2020 Jul 3;11(7):500. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 34 mg/mL (117.53 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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