StemRegenin 1

99.70%

StemRegenin 1

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品牌：源叶(MedMol)

产品编号：S80193 一键复制产品信息

CAS号：1227633-49-9

分子式：C₂₄H₂₃N₅OS

分子量：429.5373

别名：StemRegenin1; StemRegenin 1; StemRegenin 1 (SR1);

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80193-5mg买3赠1	99.70%	￥240.00 S80193-5mg ￥240.00 现货（买3赠1）	3 3	-	-	-	-
S80193-10mg买3赠1	99.70%	￥320.00 S80193-10mg ￥320.00 现货（买3赠1）	3 3	-	-	-	-
S80193-25mg买3赠1	99.70%	￥720.00 S80193-25mg ￥720.00 现货（买3赠1）	2 2	-	-	-	-
S80193-50mg买3赠1	99.70%	￥1120.00 S80193-50mg ￥1120.00 现货（买3赠1）	1 1	-	-	-	-
S80193-100mg买3赠1	99.70%	￥1920.00 S80193-100mg ￥1920.00 现货（买3赠1）	2 0 2	-	-	-	-
S80193-200mg	≥99%	￥3520.00 S80193-200mg ￥3520.00 2-3天	0 货期：2-3天	-	-	-	-
S80193-250mg	≥99%	￥3840.00 S80193-250mg ￥3840.00 2-3天	0 货期：2-3天	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.

靶点：

AhR;Aryl Hydrocarbon Receptor;AhR;ArylHydrocarbonReceptor

体外研究：

在NOD.Cg-Prkdcscid Il2rgtm1Wj1 / SzJ（NSG）小鼠中,通过SR1促进CB CD34 +细胞的增殖,能够有助于在早期进行细胞植入及持续植入

体内研究：

在体外,StemRegenin 1（1 μM）能够促进CD34 +细胞的增殖（EC 50=?120 nM）,同时降低VentX的表达水平。StemRegenin 1能够抑制光亲和配体（PAL）结合（IC 50 = 40 nM）

细胞实验：

StemRegenin 1 (SR1) is prepared in DMSO and stored, and then diluted with appropriate medium before use. A quantity of 250,000 CB-derived CD34+ cells are cultured with control conditions (DMSO, 0.01%) or StemRegenin 1 (0.75 μM) for 3 weeks. At this point control cultures had expanded 1080-fold and StemRegenin 1 treated cells expanded 2024-fold relative to starting cell numbers. A quantity of 30 to 30,000 uncultured CD34+ CB-derived cells or a fraction of the final culture equivalent to 30 to 10,000 starting cells are transplanted. The cells are injected intravenously via the retro-orbital route into sub-lethally irradiated (300 rads, 200 rads) 6- to 10-week-old NSG mice. Engraftment is performed within 24 h after irradiation. Engraftment is monitored by flow cytometric analysis of blood obtained via retro-orbital sinus or bone marrow using anti-human CD45 and anti-mouse CD45 antibodies. The mice are sacrificed between 13-16 weeks posttransplantation; bone marrow (from both femurs and tibiae), spleen and thymu

参考文献：

1. Gao H, et al. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem, 2012, 287(35), 219979-291987. 2. Gori JL, et al. Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood, 2012, 120(13), e35-44. 3. Jin H, Ji C, Ren F, et al. AHR-Mediated Oxidative Stress Contributes to the Cardiac Developmental Toxicity of Trichloroethylene in Zebrafish Embryos[J]. Journal of Hazardous Materials. 2020, 385: 121521. 4. Boitano AE, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science, 2010, 329(5997), 1345-1348.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.328 ml	11.64 ml	23.281 ml
5 mM	0.466 ml	2.328 ml	4.656 ml
10 mM	0.233 ml	1.164 ml	2.328 ml
50 mM	0.047 ml	0.233 ml	0.466 ml