| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80205-2mg买3赠1 |
99.30% | ￥262.00 |
4 | - | - | - | - |
|
S80205-5mg买3赠1 |
99.30% | ￥382.00 |
6 | - | - | - | - |
|
S80205-10mg买3赠1 |
99.30% | ￥570.00 |
6 | - | - | - | - |
|
S80205-25mg买3赠1 |
99.30% | ￥910.00 |
5 | - | - | - | - |
|
S80205-50mg促销 |
99.30% | ￥1360.00 ￥1080.00 |
5 | - | - | - | - |
|
S80205-100mg促销 |
99.30% | ￥2040.00 ￥1630.00 |
4 | - | - | - | - |
|
| 产品描述： | VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM. | ||||||||||||||||||||
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| 靶点： | ATR：13 nM (Ki)；ATM：16 μM (Ki)；DNA-PK：2.2 μM (Ki)；PI3Kγ：3.9 μM (Ki);ATM/ATR | ||||||||||||||||||||
| 参考文献： | 1. Reaper PM, et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011 Apr 13;7(7):428-30. 2. Charrier JD, et al. Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 2011 Apr 14;54(7):2320-30. 3. Prevo R, et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther. 2012 Sep;13(11):1072-81. 4. Muralidharan SV, et al. BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene. 2016 Sep 8;35(36):4689-97. | ||||||||||||||||||||
| 溶解性： | DMSO : 50 mg/mL (135.72 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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