Prulifloxacin

95.50%

Prulifloxacin

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品牌：源叶(MedMol)

产品编号：S80207 一键复制产品信息

CAS号：123447-62-1

分子式：C₂₁H₂₀FN₃O₆S

分子量：461.463

别名：普卢利沙星; 6-氟-1-甲基-7-[4-(5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基)-甲基-1-哌啶基]-4-氧代-4H-[1,3]硫氮杂环丁烷并[3,2-a]喹啉-3-羧酸; 6-氟-1-甲基-7-{4-(5-甲基-2-氧代-1,3-二噁茂烷-4-基)-甲基-1-哌啶基}-4-氧代-1H,4H-[1,3]噻啶并[3,2-A]-3-喹啉羧酸;;nm441; Sword; Quisnon;

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80207-25mg	95.50%	￥96.00 S80207-25mg ￥96.00 现货	11 >10	-	-	-	-
S80207-100mg	95.50%	￥224.00 S80207-100mg ￥224.00 现货	27 0 >10	-	-	-	-
S80207-500mg	95.50%	￥480.00 S80207-500mg ￥480.00 现货	15 >10	-	-	-	-

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产品介绍参考文献(2篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a prodrug of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis

靶点：

Quinolone;Topoisomerase;Antibacterial;Antibiotic

体内研究：

After oral administration of NM441 at a dose of 20 mg/kg to dogs, the peak concentration of NM394 in plasma was 2.39 micrograms/ml, whereas it was 0.63 micrograms/ml for NM394 administered alone. NM441 was as effective as ofloxacin and was twice as effective as ciprofloxacin against systemic infection with Staphylococcus aureus. Against infections with streptococci, NM441 was two to three times as effective as ofloxacin and five times as effective as ciprofloxacin

参考文献：

1. M Ozaki, et al. In vivo evaluation of NM441, a new thiazeto-quinoline derivative. Antimicrob Agents Chemother. 1991 Dec;35(12):2496-9. 2. Guillem Prats, et al. Prulifloxacin: a new antibacterial fluoroquinolone. Expert Rev Anti Infect Ther. 2006 Feb;4(1):27-41.

溶解性：

DMSO : 12.5 mg/mL (27.09 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.167 ml	10.835 ml	21.67 ml
5 mM	0.433 ml	2.167 ml	4.334 ml
10 mM	0.217 ml	1.084 ml	2.167 ml
50 mM	0.043 ml	0.217 ml	0.433 ml