| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80208-1mg买3赠1 |
98.10% | ￥240.00 |
9 | - | - | - | - |
|
S80208-2mg买3赠1 |
98.10% | ￥420.00 |
9 | - | - | - | - |
|
S80208-5mg买3赠1 |
98.10% | ￥580.00 |
6 | - | - | - | - |
|
S80208-10mg促销 |
98.10% | ￥1040.00 ￥832.00 |
8 | - | - | - | - |
|
S80208-25mg促销 |
98.10% | ￥2250.00 ￥1800.00 |
5 | - | - | - | - |
|
S80208-50mg促销 |
≥98% | ￥3540.00 ￥2830.00 |
货期：2-3天 | - | - | - | - |
|
S80208-100mg促销 |
≥98% | ￥5300.00 ￥4240.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation);Tyrosinase;PPAR | ||||||||||||||||||||
| 体外研究： | XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87 | ||||||||||||||||||||
| 参考文献： | 1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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