| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80244-5mg促销 |
≥98% | ￥1100.00 ￥992.00 |
6 | - | - | - | - |
|
S80244-10mg促销 |
≥98% | ￥1140.00 ￥1030.00 |
4 | - | - | - | - |
|
S80244-25mg促销 |
≥98% | ￥1520.00 ￥1370.00 |
3 | - | - | - | - |
|
S80244-50mg促销 |
≥98% | ￥2890.00 ￥2600.00 |
1 | - | - | - | - |
|
S80244-100mg促销 |
≥98% | ￥4420.00 ￥3970.00 |
2 | - | - | - | - |
|
| 产品描述： | BMS-911543 is a selective JAK2 inhibitor, with IC50s of 1.1 nM, less selective at JAK1, JAK3 and TYK2 (IC50, 75, 360, 66 nM, respectively). | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | JAK2:1.1 nM (IC50);Tyk2:66 nM (IC50);JAK1:75 nM (IC50);JAK3:360 nM (IC50);TyrosineKinases;HistoneMethyltransferase;JAK | ||||||||||||||||||||
| 体内研究： | BMS-911543 is well tolerated up to 100 mg/kg in rats (mean AUC0-72 h, 11300 μM·h) and dogs (AUC0-24 h, 610 μM·h). A 15 mg/kg/day dose (Day 14 AUC0-24 h, 3200 μM·h) is well tolerated in two-week repeat dose studies in rats. BMS-911543 (30 mg/kg, p.o.) suppresses the growth of tumor and prolongs the median survival in KPC-Brca1 mice. BMS-911543 also selectively reduces pSTAT5 expression in pancreatic tumors and decreases levels of intratumoral FoxP3+ T regulatory cells in mice administered BMS-911543 | ||||||||||||||||||||
| 参考文献： | 1. Wan H, et al. Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. ACS Med Chem Lett. 2015 Jul 12;6(8):850-5. 2. Mace TA, et al. Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. Oncotarget. 2015 Dec 29;6(42):44509-22. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京