货号	规格	价格	上海	北京	珠海	重庆	武汉
S80258-1mg买3赠1	97.86%	￥102.00 S80258-1mg ￥102.00 现货（买3赠1）	5 5 5	4	1	-	-
S80258-5mg买3赠1	97.86%	￥390.00 S80258-5mg ￥390.00 现货（买3赠1）	7 5 7	3	2	-	-
S80258-10mg买3赠1	97.86%	￥720.00 S80258-10mg ￥720.00 现货（买3赠1）	8 2 8	-	2	-	-
S80258-25mg买3赠1	97.86%	￥1270.00 S80258-25mg ￥1270.00 现货（买3赠1）	6 2 6	2	-	-	-
S80258-50mg买3赠1	97.86%	￥2290.00 S80258-50mg ￥2290.00 现货（买3赠1）	3 3	-	-	-	-
S80258-100mg买3赠1	97.86%	￥3910.00 S80258-100mg ￥3910.00 现货（买3赠1）	3 3	-	-	-	-

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产品描述：

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation

靶点：

IC50: YAP-TEAD interaction;Apoptosis;YAP;VDA;Autophagy

体内研究：

Verteporfin (10 mg/kg, c.s.c.) and BMS-354825 significantly reduces the leukemia cell ratio, and combined therapy further reduced the number of leukemia cells in the spleen

参考文献：

1. Morishita T, et al. The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with BMS-354825. Oncotarget. 2016 Aug 2. 2. Pan W, et al. Verteporfin can Reverse the NSC 125973 Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. Cell Physiol Biochem. 2016;39(2):481-90. 3. Donohue E, et al. The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.J Cancer. 2013 Aug 28;4(7):585-96.

溶解性：

DMF : 10 mg/mL (13.91 mM; ultrasonic and warming and heat to 60°C)

保存条件：

-20℃，充氮保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.391 ml	6.956 ml	13.912 ml
5 mM	0.278 ml	1.391 ml	2.782 ml
10 mM	0.139 ml	0.696 ml	1.391 ml
50 mM	0.028 ml	0.139 ml	0.278 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=5] Zijun Guo et al."YAP/TEAD-induced PRIM1 contributes to the progression and poor prognosis of gastric carcinoma."Translational Oncology.10.1016/j.tranon.2023.101791

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