| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80274-2mg买3赠1 |
96.00% | ￥222.00 |
5 | - | - | - | - |
|
S80274-5mg买3赠1 |
96.00% | ￥350.00 |
4 | - | - | - | - |
|
S80274-10mg买3赠1 |
96.00% | ￥490.00 |
5 | - | - | - | - |
|
S80274-25mg |
96.00% | ￥890.00 |
5 | - | - | - | - |
|
S80274-50mg |
≥96% | ￥1700.00 |
货期：2-3天 | - | - | - | - |
|
S80274-100mg |
≥96% | ￥2700.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | CDK1/Cyc B1:30 nM (IC50);CDK2/Cyc E:170 nM (IC50);CDK4/Cyc D1:100 nM (IC50);MAP:19000 nM (IC50);PKC:14000 nM (IC50);EGFR:22000 nM (IC50);HIVProtease;CDK;Autophagy | ||||||||||||||||||||
| 参考文献： | 1. Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273. 2. Keskin H, et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11. 3. Kim KS, et al.Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 20 mg/mL (45.63 mM) H2O : ≥ 20 mg/mL (45.63 mM) DMF : 7.69 mg/mL (17.55 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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