Pheniramine Maleate

    
98%

Pheniramine Maleate

源叶(MedMol)
S80275 一键复制产品信息
132-20-7
C20H24N2O4;C16H20N2.C4H4O4
356.42
马来酸-非尼拉敏;1-苯基-1-(2-吡啶基)-3-二甲氨基丙烷马来酸盐;1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80275-25mg 98% ¥240.00 >10 - - -
S80275-100mg 98% ¥368.00 >10 - - -
S80275-500mg 98% ¥592.00 >10 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local anesthetic, with antipruritic effects

产品描述: Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local anesthetic, with antipruritic effects
靶点: H1 Receptor:1.01 mM (IC50);5-HTReceptor;HistamineReceptor
体内研究: Pheniramine maleate (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats
参考文献: 1. Sharma A, et al. Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. Curr Drug Metab. 2003 Apr;4(2):105-29. 2. Brown RD, et al. Alpha 1-adrenergic and H1-histamine receptor control of intracellular Ca2+ in a muscle cell line: the influence of prior agonist exposure on receptor responsiveness. Mol Pharmacol. 1986 Jun;29(6):531-9. 3. Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72. 4. Hung CH, et al. Spinal anesthesia with diphenhydramine and pheniramine in rats. Eur J Pharmacol. 2011 Dec 30;673(1-3):20-4.
溶解性: H2O  :  ≥  38  mg/mL  (106.62  mM)
保存条件: -20°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.806 ml 14.028 ml 28.057 ml
5 mM 0.561 ml 2.806 ml 5.611 ml
10 mM 0.281 ml 1.403 ml 2.806 ml
50 mM 0.056 ml 0.281 ml 0.561 ml
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参考文献

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摩尔浓度计算器

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