品牌：源叶(MedMol)

产品编号：S80288 一键复制产品信息

CAS号：134523-00-5

分子式：C₆₆H₆₈CaF₂N₄O₁₀

分子量：1155.34

别名：阿伐他汀;(3R,5R)-7-[2-(4-氟苯基)-3-苯基-4-(苯基氨基甲酰基)-5-异丙基-吡咯-1-基]-3,5-二羟基庚酸;阿托伐他汀;阿伐他汀;[R-(R^<*>^,R^<*>^)]-2-(4-氟苯基)- Β,Δ-二羟基-5-(1-甲基乙基)-3-苯基-4-[(苯基氨基)羰基]-1H-吡咯-1-庚酸;阿托他汀;阿托伐他汀(钙盐);阿托伐他汀酸;(3R,5R)-7-(2-(4-氟苯基)-

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80288-5mg	≥98%	￥236.00 S80288-5mg ￥236.00 3-5天	0 货期：3-5天	-	-	-	-
S80288-10mg	≥98%	￥380.00 S80288-10mg ￥380.00 3-5天	0 货期：3-5天	-	-	-	-
S80288-50mg	≥98%	￥700.00 S80288-50mg ￥700.00 3-5天	0 货期：3-5天	-	-	-	-
S80288-100mg	≥98%	￥1040.00 S80288-100mg ￥1040.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively

靶点：

HMG-CoA Reductase (HMGCR);Autophagy;HMG-CoAReductase;Autophagy

体内研究：

Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE−/− mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment

参考文献：

1. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. 2. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. 3. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. 4. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. 5. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. 6. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.866 ml	4.328 ml	8.655 ml
5 mM	0.173 ml	0.866 ml	1.731 ml
10 mM	0.087 ml	0.433 ml	0.866 ml
50 mM	0.017 ml	0.087 ml	0.173 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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