货号	规格	价格	上海	北京	珠海	重庆	武汉
S80322-1mg买3赠1	98.49%	￥182.00 S80322-1mg ￥182.00 现货（买3赠1）	12 >10	-	-	-	-
S80322-5mg买3赠1	98.49%	￥320.00 S80322-5mg ￥320.00 现货（买3赠1）	14 >10	-	-	-	-
S80322-10mg买3赠1	98.49%	￥480.00 S80322-10mg ￥480.00 现货（买3赠1）	9 9	-	-	-	-
S80322-25mg买3赠1	98.49%	￥760.00 S80322-25mg ￥760.00 现货（买3赠1）	3 3	-	-	-	-
S80322-50mg买3赠1	98.49%	￥1140.00 S80322-50mg ￥1140.00 现货（买3赠1）	6 6	-	-	-	-
S80322-100mg买3赠1	98.49%	￥1710.00 S80322-100mg ￥1710.00 现货（买3赠1）	3 0 3	-	-	-	-

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产品描述：

4μ8C(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.

靶点：

IRE1

体内研究：

4μ8C reverses the ER stress-dependent loss of several known RIDD targets, with an EC50 of approximately 4 μM, approximating that of inhibition of XBP1 target gene activation

细胞实验：

Cells are seeded in phenol red-free cell culture medium in 96 or 24 well dishes at a density of 5 × 103 or 5 × 104 cells per well, respectively. Cultures are incubated for 16 h before treatment with 4μ8C for 24 h. Cultures are then analyzed by the addition of 200 μM WST1 and 10 μM phenazine metho-sulfate. After development of the reagent for 2 h at 37°C, the hydrolyzed dye is detected by absorbance at 450 nm, after subtracting background and absorbance at 595 nm. Alternatively, cell viability is determined by staining of the adherent culture with crystal violet. Quantitation of the dye uptake is analyzed by extensive washing of the stained cells with water and solublization of the crystal violet in methanol followed by absorbance measurements at 595 nm. (Only for Reference)

参考文献：

1.Cross BC, et al. Proc Natl Acad Sci U S A. 2012, 109(15), E869-878. 2.Kemp KL, et al. J Biol Chem. 2013, 288(46), 33272-33282.

溶解性：

DMSO:20.4 mg/mL (100 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.898 ml	24.488 ml	48.976 ml
5 mM	0.98 ml	4.898 ml	9.795 ml
10 mM	0.49 ml	2.449 ml	4.898 ml
50 mM	0.098 ml	0.49 ml	0.98 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

8-Formyl-4-methylumbelliferone