| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80341-5mg促销 |
98.60% | ￥120.00 ￥96.00 |
9 | - | - | - | - |
|
S80341-10mg促销 |
98.60% | ￥154.00 ￥138.00 |
9 | - | - | - | - |
|
S80341-50mg |
98.60% | ￥530.00 |
2 | - | - | - | - |
|
S80341-100mg |
≥98% | ￥1020.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway | ||||||||||||||||||||
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| 靶点： | EGFR;IκB/IKK | ||||||||||||||||||||
| 体外研究： | WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC50 value of 0.28 μM. WS3 (1.0 nM-1.0 µM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments. |
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| 体内研究： | 在小鼠β细胞系R7T1中,WS3诱导细胞增殖（EC50=0.074 μM）。在原代胚胎和成人视网膜色素上皮细胞中,WS3可逆诱导细胞发生增殖 | ||||||||||||||||||||
| 细胞实验： | R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference) | ||||||||||||||||||||
| 参考文献： | 1. Shen W, et al. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. 2. Swoboda JG, et al. Small molecule mediated proliferation of primary retinal pigment epithelial cells. ACS Chem Biol. 2013, 8(7), 1407-1411. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京