货号	规格	价格	上海	北京	珠海	重庆	武汉
S80377-5mg	98.42%	￥172.00 S80377-5mg ￥172.00 现货	5 0 5	-	-	-	-
S80377-10mg	98.42%	￥244.00 S80377-10mg ￥244.00 现货	4 4	-	-	-	-
S80377-25mg买3赠1	98.42%	￥518.00 S80377-25mg ￥518.00 现货（买3赠1）	5 5	-	-	-	-
S80377-50mg	98.42%	￥720.00 S80377-50mg ￥720.00 现货	2 0 2	-	-	-	-
S80377-100mg买3赠1	98.42%	￥1101.00 S80377-100mg ￥1101.00 现货（买3赠1）	1 1	-	-	-	-

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产品描述：

Doripenem is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens. Target: Antibacterial Doripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem. Doripenem appears as crystalline powder anywhere from a white to somewhat yellowish colour.Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also solution in N,N-dimethylformamide. Doripenem's chemical configuration has 6 asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powered drug can form a monohydrate when mixed with water. However, Doripenem has not been proven to possess polymorphism.

靶点：

β-lactam;Antibacterial;Antibiotic

体内研究：

Doripenem (S 4661；MIC 范围为 2 至 16 μg/ml；皮下注射；1 小时和 4 小时输注；0.2 ml 注射) 显示出对铜绿假单胞菌的抗菌作用。
Doripenem (10、50、150 mg/kg；0.2 ml 体积；皮下注射 2 小时) 在 10 mg/kg 剂量对小鼠的 T1/2 为 0.41 小时，CL 为 673.9 mL/h•kg。
Pharmacokinetic Parameters of Doripenem in mice.

参考文献：

1. Anderson DL. Doripenem. Drugs Today (Barc). 2006 Jun;42(6):399-404. 2. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.378 ml	11.89 ml	23.781 ml
5 mM	0.476 ml	2.378 ml	4.756 ml
10 mM	0.238 ml	1.189 ml	2.378 ml
50 mM	0.048 ml	0.238 ml	0.476 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=11.8] Huaning Li, et al. "KRT18 promotes the high-grade meningioma proliferation by interacting with LDHA to activate glycolysis and the PI3K/AKT signaling pathway"CANCER LETTERS, 2026 Sep;656:218680

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

多利培南

Doripenem

参考文献(1篇)

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)