货号	规格	价格	上海	北京	珠海	重庆	武汉
S80391-5mg买3赠1	99.23%	￥200.00 S80391-5mg ￥200.00 现货（买3赠1）	3 3	-	-	-	-
S80391-10mg买3赠1	99.23%	￥374.00 S80391-10mg ￥374.00 现货（买3赠1）	7 7	-	-	-	-
S80391-50mg买3赠1	99.23%	￥540.00 S80391-50mg ￥540.00 现货（买3赠1）	1 0 1	-	-	-	-
S80391-100mg买3赠1	≥99%	￥920.00 S80391-100mg ￥920.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S80391-200mg买3赠1	≥99%	￥1650.00 S80391-200mg ￥1650.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator

靶点：

p38:50 nM (IC50);p38β2:500 nM (IC50);Apoptosis;p38MAPK;Autophagy

体内研究：

Adezmapimod (SB 203580) (5 mg/kg/day; intra peritoneal injected daily for 16 consecutive days, in female atymic Nu/Nu mice) treatment, p38WT tumors show a significantly smaller tumor burden when compared with p38TM tumors that were treated in parallel

参考文献：

1. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. 2. Lali FV, et al. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitoge 3. Leelahavanichkul K, et al. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb;8(1):105-18.

溶解性：

DMSO : 20 mg/mL (52.99 mM; ultrasonic and warming and heat to 60°C)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.649 ml	13.247 ml	26.495 ml
5 mM	0.53 ml	2.649 ml	5.299 ml
10 mM	0.265 ml	1.325 ml	2.649 ml
50 mM	0.053 ml	0.265 ml	0.53 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(3篇)

3. [IF=5.5] Waimei Si et al."Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R."CNS Neuroscience & Therapeutics".2024 Apr;30(4):e14657 2. [IF=3.887] Li TENG et al."Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo."Chinese Journal of Natural Medicines.2023 Feb;21:99 1. [IF=4.657] Shen, Yue et al."Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study."INFLAMMATION.2022 Nov;:1-24

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