源叶(MedMol)
S80402
一键复制产品信息
15421-84-8
C10H15N5
205.26
曲匹地尔;7-(二乙基氨基)-5-甲基-s-噻唑并[1,5-a]嘧啶; 5-甲基-7-二乙胺基-1,2,4-三唑并[5,1-A]嘧啶; 乐可安;;(1,2,4)Triazolo(1,5-a)pyrimidin-7-amine,N,N-diethyl-5-methyl; diethyl-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-amine; Tr
Trapidil 99.55%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80402-5mg |
99.55% | ￥150.00 |
>10 | - | - | - | - |
|
S80402-10mg |
99.55% | ￥230.00 |
>10 | - | - | - | - |
|
S80402-50mg |
99.55% | ￥770.00 |
>10 | - | - | - | - |
|
S80402-250mg |
99.55% | ￥3200.00 |
>10 | - | - | - | - |
|
| 产品描述： | Trapidil is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | PDGFR;PDE | ||||||||||||||||||||
| 体内研究： | Trapidil is an antiplatelet drug with specific platelet-derived growth factor antagonism and antiproliferative effects in the rat and rabbit models after balloon angioplasty. Trapidil had a potent inhibitory effect on osteoclast formation and bone resorption induced by interleukin-1 in an animal model. No abnormal symptoms, such as changes in body weight, diarrhea, high fever, and convulsion, were observed after intraperitoneal injections of trapidil | ||||||||||||||||||||
| 细胞实验： | Cell viability was determined by Trypan blue dye exclusion test and LDH assay. Supernatants, collected from cells seeded in serum-free medium and exposed to the different mitogens and drugs tested, were centrifuged and LDH concentration determined. Supernatants obtained from sonicated cells were used as a positive control. Furthermore, to definitely exclude a cytotoxic effect of Trapidil on human MC, cells incubated for four days with and without the drug were challenged with fresh medium containing 10% FBS, and cell proliferation evaluated. (Only for Reference) | ||||||||||||||||||||
| 参考文献： | 1.Gesualdo L, et al. Kidney Int. 1994, 46(4):1002-9. 2.Kim SD, et al. Biochem Pharmacol. 2013, 86(6):782-90. 3.Maresta A, et al. Circulation. 1994, 90(6):2710-5. | ||||||||||||||||||||
| 溶解性： | Ethanol:39 mg/mL (190 mM) DMSO:39 mg/mL (190 mM) H2O:38 mg/mL (185.1 mM) | ||||||||||||||||||||
| 保存条件： | -20℃,避光 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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