货号	规格	价格	上海	北京	珠海	重庆	武汉
S80405-5mg	≥98%	￥800.00 S80405-5mg ￥800.00 3-5天	0 货期：3-5天	-	-	-	-
S80405-10mg	≥98%	￥1200.00 S80405-10mg ￥1200.00 3-5天	0 货期：3-5天	-	-	-	-
S80405-50mg	≥98%	￥4000.00 S80405-50mg ￥4000.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

LY303511 is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells.

靶点：

TRAIL IC50: 64.6±9.1 µM (K+ currents, in MIN6 insulinoma cells);PotassiumChannel;TNF;mTOR

体内研究：

Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm3, at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo

参考文献：

1. Bodenstine TM, et al. Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. Cancer Res. 2010 Dec 1;70(23):10002-11. 2. El-Kholy W, Macdonald PE, Lin JH, The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J. 2003 Apr;17(6):720-2. 3. Shenoy K, et al. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res. 2009 Mar 1;69(5):1941-50. 4. Kristof AS, et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J Pharmacol E

溶解性：

10 mM in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.264 ml	16.321 ml	32.642 ml
5 mM	0.653 ml	3.264 ml	6.528 ml
10 mM	0.326 ml	1.632 ml	3.264 ml
50 mM	0.065 ml	0.326 ml	0.653 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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LY 303511