| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
| 源叶(MedMol) | S80421-2mg | 98% | ￥240.00元 | 4 | - | - | - |
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| 源叶(MedMol) | S80421-5mg | 98% | ￥320.00元 | 5 | - | - | - |
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| 源叶(MedMol) | S80421-10mg | 98% | ￥390.00元 | 2 | - | - | - |
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| 源叶(MedMol) | S80421-25mg | 98% | ￥782.00元 | 5 | - | - | - |
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| 源叶(MedMol) | S80421-50mg | 98% | ￥1360.00元 | 6 | - | - | - |
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| 源叶(MedMol) | S80421-100mg | 98% | ￥1650.00元 | 4 | - | - | - |
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| 产品描述： | TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM). | ||||||||||||||||||||
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| 靶点： | IC50: 5 nM (MTH1);DNA/RNASynthesis;MTH1 | ||||||||||||||||||||
| 体外研究： | TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM. Cell Viability Assay[1] Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells Concentration: 2, 4, 6, 8, 10 μM Incubation Time: 7-10 days Result: Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, but was less toxic to several primary or immortalized cells. | ||||||||||||||||||||
| 体内研究： | TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model. Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model) Dosage: 30 mg/kg Administration: Subcutaneous injection; once daily for 35 days Result: Reduced tumour growth in SW480 xenograft cancer model. | ||||||||||||||||||||
| 参考文献： | 1. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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