货号	规格	价格	上海	北京	珠海	重庆	武汉
S80437-1mg促销	99.20%	￥170.00 ￥136.00 S80437-1mg ￥136.00 现货	7 7	-	-	-	-
S80437-2mg促销	99.20%	￥306.00 ￥244.00 S80437-2mg ￥244.00 现货	6 6	-	-	-	-
S80437-5mg促销	99.20%	￥578.00 ￥462.00 S80437-5mg ￥462.00 现货	5 5	-	-	-	-
S80437-10mg促销	99.20%	￥986.00 ￥788.00 S80437-10mg ￥788.00 现货	4 0 4	-	-	-	-
S80437-25mg	≥99%	￥1900.00 S80437-25mg ￥1900.00 2-3天	0 货期：2-3天	-	-	-	-
S80437-50mg	≥99%	￥3100.00 S80437-50mg ￥3100.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

FIIN-2 is an irreversible inhibitor of FGFR with an IC50 of 3.1, 4.3, 27, and 45 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.

靶点：

FGFR1:3.1 nM (IC50);FGFR2:4.3 nM (IC50);FGFR3:27 nM (IC50);FGFR4:45 nM (IC50);FGFR

体外研究：

FIIN-2 potently inhibits WT FGFRs (EC50s in the 1- to 93-nM range) and the gatekeeper mutant of FGFR2 (EC50 of 58 nM). FIIN-2 also moderately inhibits EGFR, with an IC50 of 204 nM. FIIN-2 inhibits proliferation of FGFR1-4 Ba/F3 cells with EC50s in the single- to double-digit nanomolar range and are especially potent against FGFR2, with EC50s in the 1-nM range. FIIN-2 shows good potency against gatekeeper mutant V564F

体内研究：

Treatment of fish in the embryonic state with either FIIN-2 causes defects to the posterior mesoderm similar to the phenotypes reported following genetic knockdown of FGFR or treatment with other reported FGFR inhibitors. FIIN-2 causes mild or severe phenotypes to the tail morphogenesis in all treated embryonic zebrafish

参考文献：

1. Tan L, et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-4877.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.575 ml	7.877 ml	15.755 ml
5 mM	0.315 ml	1.575 ml	3.151 ml
10 mM	0.158 ml	0.788 ml	1.575 ml
50 mM	0.032 ml	0.158 ml	0.315 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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