| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80444-5mg买3赠1 |
99.80% | ￥230.00 |
4 | - | - | - | - |
|
S80444-10mg买3赠1 |
99.80% | ￥370.00 |
5 | - | - | - | - |
|
S80444-25mg买3赠1 |
99.80% | ￥760.00 |
4 | - | - | - | - |
|
S80444-50mg买3赠1 |
99.80% | ￥1280.00 |
3 | - | - | - | - |
|
S80444-100mg买3赠1 |
99.80% | ￥2240.00 |
2 | - | - | - | - |
|
S80444-250mg |
99.80% | ￥3600.00 |
3 | - | - | - | - |
|
| 产品描述： | Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively. Avasimibe can be used for the research of prostate cancer | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | ACAT1:24 μM (IC50)；ACAT2：9.2 μM (IC50);P450;Acyltransferase | ||||||||||||||||||||
| 体内研究： | Avasimibe (30 mg/kg, intraperitoneally injected on alternate days for 7 weeks) suppresses PCa cell growth and metastasis in vivo. Avasimibe has good biocompatibility and low toxicity | ||||||||||||||||||||
| 参考文献： | 1. Taichi Ohshiro,et al. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15. 2. Kangping Xiong, et al. The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer.Cancer Cell Int. 2021 Aug 30;21(1):461. | ||||||||||||||||||||
| 溶解性： | DMSO : 100 mg/mL (199.31 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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