| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80446-2mg促销 |
99.70% | ￥119.00 ￥95.00 |
8 | - | - | - | - |
|
S80446-1mg买3赠1 |
99.70% | ￥102.00 |
7 | - | - | - | - |
|
S80446-5mg促销 |
99.70% | ￥160.00 ￥128.00 |
8 | - | - | - | - |
|
S80446-10mg促销 |
99.70% | ￥314.00 ￥250.00 |
6 | - | - | - | - |
|
S80446-25mg促销 |
99.70% | ￥510.00 ￥459.00 |
5 | - | - | - | - |
|
S80446-50mg |
≥98% | ￥860.00 |
货期：2-3天 | - | - | - | - |
|
S80446-100mg |
≥98% | ￥1540.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM[1]. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner | ||||||||||||||||||||
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| 靶点： | Mcl-1:0.45 nM (Ki);Bcl-2:132 nM (Ki);Bfl-1:660 nM (Ki);Bcl-W:2280 nM (Ki);Apoptosis;Apoptosis;BCL | ||||||||||||||||||||
| 体外研究： | A-1210477 (10 μM) reduces the amount of BIM co-immunoprecipitated with MCL-1 antibody, and triggers MCL-1 elevation in a variety of cancer cell lines, including the breast cancer cell line HCC-1806. A-1210477 inhibits MCL-1-NOXA interactions with an IC50 of approximately 1 μM, while having no effect on BCL-2-BIM or BCL-XL-BCL-XS interactions. The NSCLC cell lines H2110 and H23 are sensitive to A-1210477 with cell viability IC50<10 μM, confirming that A-1210477 can kill MCL-1-dependent cell lines | ||||||||||||||||||||
| 参考文献： | 1. Leverson JD, et al. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). Cell Death Dis. 2015 Jan 15;6:e1590. 2. Qing Wang, et al. A-1210477, a selective MCL-1 inhibitor, overcomes ABT-737 resistance in AML. Oncol Lett. 2019 Nov;18(5):5481-5489. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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