货号	规格	价格	上海	北京	珠海	重庆	武汉
S80448-1mg买3赠1	99.30%	￥144.00 S80448-1mg ￥144.00 现货（买3赠1）	7 7	-	-	-	-
S80448-2mg买3赠1	99.30%	￥280.00 S80448-2mg ￥280.00 现货（买3赠1）	3 3	-	-	-	-
S80448-5mg买3赠1	99.30%	￥640.00 S80448-5mg ￥640.00 现货（买3赠1）	2 2	-	-	-	-
S80448-10mg买3赠1	99.30%	￥1120.00 S80448-10mg ￥1120.00 现货（买3赠1）	2 2	-	-	-	-
S80448-25mg买3赠1	99.30%	￥2240.00 S80448-25mg ￥2240.00 现货（买3赠1）	5 0 5	-	-	-	-
S80448-100mg买3赠1	≥99%	￥3240.00 S80448-100mg ￥3240.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1)是一种PD-1/PD-L1相互作用的小分子化合物抑制剂，IC50为6 nM

靶点：

PD-1/PD-L1 interaction(Cell-free assay):0.006 μM;Apoptosis;PD-1/PD-L1

体外研究：

PD-1/PD-L1 inhibitor 1 causes half-reduced cell viability at lower concentrations in triple-negative breast cancer (TNBC), activates ERK in MDA-MB-231 and MCF7, significantly increases IL-8 expression in MDA-MB-231 and HCC1806 when administrated in combination with ERK1/2 inhibitor, also potently downregulates the IL-8 expression to its half amount in MDA-MB-231

体内研究：

PD-1/PD-L1 inhibitor 1 combined with Jiedu Sangen Decoction (JSD) remarkably inhibits and reverses epithelial-mesenchymal transition (EMT) via PI3K/AKT signaling pathway

细胞实验：

Cell lines: MDA-MB-231 cells, HCC1937 cells, HCC1806 cells, MCF7 cells Concentrations: -- Incubation Time: 72 h Method: Cell proliferation is determined by the MTS assay. A total of 1-2×103 cells are plated in 100 μl medium in each well of a 96-well plate. After 24 h, PD-1/PD-L1 inhibitor 1 and ERK1/2 inhibitor are diluted to the desired concentrations in test medium (DMEM containing 1% fetal bovine serum) and added as single or as combined treatment in triplicate for 72 h.

动物实验：

Animal Models: Male specific pathogen free BALB/c mice of hepatic metastatic colorectal cancer (CRC) model Dosages: 100 µg Administration: i.p.

参考文献：

1. WO/2015/034820, COMPOUNDS USEFUL AS IMMUNOMODULATORS. 2. Bräutigam K, et al. Inhibitors of PD-1/PD-L1 and ERK1/2 impede the proliferation of receptor positive and triple-negative breast cancer cell lines. J Cancer Res Clin Oncol. 2021;147(10):2923-2933. 3. Shan, Feiyu et al. Inhibition to Epithelial-Mesenchymal Transition and Metastatic Potential In Colorectal Cancer Cell By Combination of Traditional Chinese Medicine Formulation Jiedu Sangen Decoction and PD-L1 Inhibitor. Integrative cancer therapies vol. 19 (2020): 1534735420972486.

溶解性：

Soluble in DMSO、Ethanol、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.103 ml	10.514 ml	21.027 ml
5 mM	0.421 ml	2.103 ml	4.205 ml
10 mM	0.21 ml	1.051 ml	2.103 ml
50 mM	0.042 ml	0.21 ml	0.421 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=3.7] Fu Shulin et al."Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways."VETERINARY RESEARCH.2024 Dec;55(1):1-17

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PD1-PDL1 inhibitor 1