Efaproxiral sodium

99.70%

Efaproxiral sodium

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品牌：源叶(MedMol)

产品编号：S80455 一键复制产品信息

CAS号：170787-99-2

分子式：C₂₀H₂₂NNaO₄

分子量：363.383

别名：乙丙昔罗钠;2-[4-[2-[(3,5-二甲基苯基)氨基]-2-氧代乙基]苯氧基]-2-甲基丙酸钠;EFAPROXIRAL SODIUM;Sodium 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoate;2-[4-[2-(3,5-Dimethylphenylamino)-2-oxoethyl]phen

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80455-10mg促销	99.70%	￥112.00 ￥89.00 S80455-10mg ￥89.00 现货	19 >10	-	-	-	-
S80455-50mg	99.70%	￥370.00 S80455-50mg ￥370.00 现货	6 6	-	-	-	-
S80455-200mg	99.70%	￥1090.00 S80455-200mg ￥1090.00 现货	3 0 3	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Efaproxiral Sodium , a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.

靶点：

Reactive Oxygen Species;ReactiveOxygenSpecies

体内研究：

Efaproxiral plus oxygen breathing reduces the radiobiological hypoxic fraction of EMT6 tumors from the value of 24% found in both air-breathing and oxygen-breathing mice to 9% and improves the response of the tumors to radiation. Carboplatin (100 mg/kg) slowes tumor growth in air-breathing mice, producing a growth delay of 3.3 days. Efaproxiral plus oxygen increases the growth delay to 5.7 days; this is 2.4 days (71%) greater than that for carboplatin alone and 2.1 days (57%) greater than that for carboplatin plus oxygen breathing. Efaproxiral plus oxygen breathing, therefore, improves the tumor growth delay obtained with 100 mg/kg carboplatin to or beyond that obtained with the highly toxic dose of 150 mg/kg carboplatin, but does so without increasing the toxicity beyond that seen with 100 mg/kg carboplatin in air-breathing mice. Efaproxiral significantly increases tumor oxygenation by 8.4 to 43.4 mmHg within 5 days in C3H mice with RIF-1 tumors, with maximum increases at 22-31 min after treatment. Efaproxiral plus oxygen plus Radiation produces tumor growth inhibition throughout the treatment duration in C3H mice with RIF-1 tumors, and inhibition is significantly different from radiation plus oxygen from day 3 to day 5.

参考文献：

1.Donnelly ET, et al. Exp Biol Med (Maywood), 2006, 231(3), 317-321. 2.Hou H, et al. Radiat Res, 2007, 168(2), 218-225.

溶解性：

H2O:67 mg/mL (184.4 mM) DMSO:68 mg/mL (187.1 mM) Ethanol:68 mg/mL (187.1 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.752 ml	13.76 ml	27.519 ml
5 mM	0.55 ml	2.752 ml	5.504 ml
10 mM	0.275 ml	1.376 ml	2.752 ml
50 mM	0.055 ml	0.275 ml	0.55 ml