| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80459-2mg买3赠1 |
98.20% | ￥300.00 |
5 | - | - | - | - |
|
S80459-5mg买3赠1 |
98.20% | ￥600.00 |
1 | - | - | - | - |
|
S80459-10mg买3赠1 |
98.20% | ￥960.00 |
7 | - | - | - | - |
|
S80459-25mg买3赠1 |
98.20% | ￥2000.00 |
4 | - | - | - | - |
|
S80459-50mg买3赠1 |
98.20% | ￥3220.00 |
2 | - | - | - | - |
|
S80459-100mg |
≥98% | ￥4970.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | sPLA2:9 nM (IC50);Phospholipase | ||||||||||||||||||||
| 体内研究： | Varespladib treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib is 16.1 mg/kg | ||||||||||||||||||||
| 参考文献： | 1. Snyder DW, et al. Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1 2. Hori Y, et al. Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61. | ||||||||||||||||||||
| 溶解性： | DMSO : 100 mg/mL (262.89 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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