| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80461-1mg买3赠1 |
98.07% | ￥220.00 |
7 | - | - | - | - |
|
S80461-2mg买3赠1 |
98.07% | ￥310.00 |
9 | - | - | - | - |
|
S80461-5mg买3赠1 |
98.07% | ￥490.00 |
5 | - | - | - | - |
|
S80461-10mg买3赠1 |
98.07% | ￥730.00 |
8 | - | - | - | - |
|
S80461-25mg买3赠1 |
98.07% | ￥1160.00 |
8 | - | - | - | - |
|
S80461-50mg买3赠1 |
98.07% | ￥1740.00 |
5 | - | - | - | - |
|
S80461-100mg买3赠1 |
98.07% | ￥2610.00 |
4 | - | - | - | - |
|
| 产品描述： | PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC50s of 4 and 5 nM for Lck and Fyn, respectively. | ||||||||||||||||||||
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| 靶点： | IC50: 4 nM (Lck), 5 nM (Fyn);EGFR;TyrosineKinases;JAK;Src | ||||||||||||||||||||
| 体内研究： | The tumor growth inhibition rate is 25% in the PP2 treatment group and 5% in the Gemcitabine treatment group (P>0.05). When administered in combination, PP2 and Gemcitabine produce a tumor growth inhibition rate of 98% (P<0.05). Hepatic metastasis occurred in 100% of control and Gemcitabine-treated groups; 88% of the PP2-treated group developed liver metastases. There are no detectable metastases in the group treated with PP2 and Gemcitabine in combination (P<0.05) | ||||||||||||||||||||
| 参考文献： | 1. Hanke JH, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck-and FynT-dependentT cell activation. J Biol Chem. 1996 Jan 12;271(2):695-701. 2. Duxbury MS, et al. Inhibition of SRC tyrosine kinase impairs inherent and acquired Gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin Cancer Res. 2004 Apr 1;10(7):2307-18 3. Summy JM, et al. AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol Cancer Ther. 2005 D 4. Inoue A, et al. Phosphorylation of NMDA receptor GluN2B subunit at Tyr1472 is important for trigeminal processing of itch. Eur J Neurosci. 2016 Oct;44(7):2474-2482. | ||||||||||||||||||||
| 溶解性： | DMSO : 50 mg/mL (165.69 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京