货号	规格	价格	上海	北京	珠海	重庆	武汉
S80472-2mg买3赠1	98.90%	￥90.00 S80472-2mg ￥90.00 现货（买3赠1）	4 4	-	-	-	-
S80472-5mg买3赠1	98.90%	￥180.00 S80472-5mg ￥180.00 现货（买3赠1）	5 5	-	-	-	-
S80472-10mg买3赠1	98.90%	￥300.00 S80472-10mg ￥300.00 现货（买3赠1）	4 4	-	-	-	-
S80472-25mg买3赠1	98.90%	￥600.00 S80472-25mg ￥600.00 现货（买3赠1）	6 6	-	-	-	-
S80472-50mg买3赠1	98.90%	￥1000.00 S80472-50mg ￥1000.00 现货（买3赠1）	5 5	-	-	-	-
S80472-100mg买3赠1	98.90%	￥1600.00 S80472-100mg ￥1600.00 现货（买3赠1）	5 0 5	-	-	-	-
S80472-200mg买3赠1	≥98%	￥2800.00 S80472-200mg ￥2800.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.

靶点：

IC50: 1.5 μM (p97), 11.5 μM (Vps4);Apoptosis;p97;Autophagy

体外研究：

DBeQ is a ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively. DBeQ inhibits p97 competitively with respect to ATP, with a Ki of 3.2 ± 0.4 μM. DBeQ inhibits degradation of the p97-dependent substrate UbG76V-GFP, with IC50 value of 2.6 μM. DBeQ (10 μM) also significantly suppresses degradation of TCRα-GFP, induces CHOP but does not increase p21 level. Moreover, DBeQ inhibits the viability of MRC-5, Hek293, HeLa and RPMI8226 cells, with GI50s of 6.6 ± 2.9, 4 ± 0.6, 3.1 ± 0.5 and 1.2 ± 0.3, respectively. DBeQ potently inhibits the AAA ATPase p97 by specifically binding to the ATPase site of its D2 domain (p97D2). DBeQ also inhibits Vps4, with an IC50 of 11.5 μM. Furthermore, DBeQ (30 μM) inhibits hyphal growth of the wild-type cell (strain YLZ0)

参考文献：

1. Chou TF, et al.Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. 2. Zhang Y, et al. The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ. Mycopathologia. 2016 Jun;181(5-6):329-39.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.938 ml	14.688 ml	29.375 ml
5 mM	0.588 ml	2.938 ml	5.875 ml
10 mM	0.294 ml	1.469 ml	2.938 ml
50 mM	0.059 ml	0.294 ml	0.588 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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