BAY-876 99.60%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80476-2mg |
99.60% | ￥544.00 |
1 | - | - | - | - |
|
S80476-5mg |
≥98% | ￥782.00 |
货期：2-3天 | - | - | - | - |
|
S80476-10mg |
99.60% | ￥1220.00 |
1 | 1 | - | - | - |
|
S80476-25mg |
≥98% | ￥2240.00 |
货期：2-3天 | - | - | - | - |
|
S80476-50mg |
≥98% | ￥3870.00 |
货期：2-3天 | - | - | - | - |
|
S80476-100mg |
≥98% | ￥5556.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4[1]. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth | ||||||||||||||||||||
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| 靶点： | GLUT1:2 nM (IC50);GLUT2:10.08 μM (IC50);GLUT3:1.67 μM (IC50);GLUT4;0.29 μM (IC50);transporter | ||||||||||||||||||||
| 体外研究： | BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells. Cell Proliferation Assay Cell Line: SKOV-3 and OVCAR-3 cells Concentration: 25, 50, 75 nM Incubation Time: 24 and 72 hours Result: Led to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells. | ||||||||||||||||||||
| 体内研究： | BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice. Animal Model: Female NOD-scid IL2rgnull (NSG) mice carrying SKOV-3 subcutaneous (s.c.) xenografts Dosage: 1.5, 3, 4.5 mg/kg Administration: Oral administration; daily; for 28 days Result: Caused a clear dose-dependent inhibition of tumorigenicity. | ||||||||||||||||||||
| 参考文献： | 1. Siebeneicher H et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Aug 23. 2. Ma Y, et al. Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers (Basel). 2018 Dec 31;11(1). | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Methanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(2篇)
2. [IF=15.7] Yang Ye et al."Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging."Nature Communications.2025 Jul;16(1):1-13
1. [IF=11.467] Chao Li et al."Core-shell nanosystems designed for effective oral delivery of polypeptide drugs."JOURNAL OF CONTROLLED RELEASE.2022 Dec;352:540
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