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Ciproxifan Maleate

    
≥98%(HPLC)

CIPROXIFAN

源叶(MedMol)
S80490 一键复制产品信息
184025-19-2
C16H18N2O2.C4H4O4
386.398
环丙基[4-[3-(1H-咪唑-4-基)丙氧基]苯基]甲酮马来酸盐;CIPROXIFAN 马来酸盐;马来酸盐形式;CIPROXIFAN;FUB 359 maleate salt, Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt;FUB 359 Maleate salt;Methanone, cycl;CIPROXIFAN
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S80490-1mg促销
≥98%(HPLC)

¥200.00 ¥180.00

3 - - - -
S80490-5mg促销
≥98%(HPLC)

¥500.00 ¥450.00

8 - - - -
S80490-10mg促销
≥98%(HPLC)

¥900.00 ¥810.00

4 - - - -
S80490-25mg促销
≥98%(HPLC)

¥1700.00 ¥1530.00

3 - - - -
S80490-50mg促销
≥98%(HPLC)

¥3000.00 ¥2700.00

2 - - - -
S80490-100mg促销
≥98%(HPLC)

¥4600.00 ¥4140.00

1 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Ciproxifan maleate (FUB 359 maleate) is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan maleate displays low apparent affinity at other receptor subtypes. Ciproxifan maleate can be used for the research of aging disorders and Alzheimer's disease
靶点: H3 receptor:9.2 nM (IC50);HistamineReceptor
体内研究: Ciproxifan (1 mg/kg; a single p.o.) increases the t-MeHA level in mouse brain, with an ED50 of 0.14 mg/kg. Ciproxifan (3 mg/kg, i.p.) improves the accuracy of responding in the five-choice task in rats only when the stimulus duration is 0.25 sec instead of 0.50 sec. Ciproxifan (0.15-2 mg/kg; p.o.) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats. Ciproxifan (1 mg/kg; a single i.v.) decreases the H3-receptor ligand concentration in serum in mice, with the half-lives (t1/2) of 13 and 87 min for the distribution and elimination phases in mice, respectively. Ciproxifan (1 mg/kg; a single p.o.) exhibits oral bioavailability (F=62%) and maximal concentration (Cmax=420 nM) in mice
参考文献: 1. Ligneau X, et, al. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther. 1998 Nov;287(2):658-66. 2. Motawaj M, Arrang JM. Ciproxifan, a histamine H3-receptorantagonist / inverse agonist, modulates methamphetamine-induced sensitization in mice. Eur J Neurosci. 2011 Apr;33(7):1197-204. doi: 10.1111/j.1460-9568.2011.07618.x. 3. Bardgett ME, Davis NN, Schultheis PJ, Griffith MS. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72. 4. Bardgett ME, Points M, Kleier J, Blankenship M, Griffith MS. The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats. Neuropharmacology. 2010 Nov;59(6):492-502. 5. Day M, et al . Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test. Biochem Pharmacol. 2007 Apr 15;73(8):1123-34. 6. Pillot C, Héron A, Schwartz JC, Arrang JM. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum. Eur J Neurosci. 2003 Jan;17(2):307-14.
溶解性: Soluble  in  DMSO、H2O
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.588 ml 12.94 ml 25.88 ml
5 mM 0.518 ml 2.588 ml 5.176 ml
10 mM 0.259 ml 1.294 ml 2.588 ml
50 mM 0.052 ml 0.259 ml 0.518 ml
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参考文献

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