货号	规格	价格	上海	北京	武汉	南京
S80517-5mg	99.3%	￥190.00 S80517-5mg ￥190.00 现货	4 4	-	-	-
S80517-10mg	99.3%	￥310.00 S80517-10mg ￥310.00 现货	6 6	-	-	-
S80517-25mg	99.3%	￥610.00 S80517-25mg ￥610.00 现货	6 6	-	-	-
S80517-50mg	99.3%	￥970.00 S80517-50mg ￥970.00 现货	5 5	-	-	-
S80517-100mg	≥99%	￥1560.00 S80517-100mg ￥1560.00 2-3天	0 货期：2-3天	-	-	-
S80517-200mg	≥99%	￥2800.00 S80517-200mg ￥2800.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations

产品描述：

Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations

靶点：

Hydroxylase

体内研究：

Ro 61-8048 (50, 100 and 150 mg/kg i.p.) significantly reduces the severity of dystonia in dtsz hamsters without leading to marked central side effects. Ro 61-8048 (100 mg/kg i.p.) provokes a two- to threefold increase of the endogeneous broad spectrum glutamate receptor antagonist kynurenic acid in the striatum, cerebellum and brainstem of mutant hamsters.

参考文献：

1. S Röver, et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40(26):4378-85. 2. Melanie Hamann, et al. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant. Eur J Pharmacol. 2008 May 31;586(1-3):156-9. 3. AlbertoChiarugi, et al. Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl) thiazol-2yl]-benzenesulfonamide (Ro 61-8048), two potent and selective inhibitors of kynureni

溶解性：

DMSO : ≥ 59 mg/mL (139.99 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.373 ml	11.864 ml	23.728 ml
5 mM	0.475 ml	2.373 ml	4.746 ml
10 mM	0.237 ml	1.186 ml	2.373 ml
50 mM	0.047 ml	0.237 ml	0.475 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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RO 61-8048

3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide