| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80519-1mg买3赠1 |
99.90% | ￥60.00 |
>10 | - | - | - | - |
|
S80519-5mg |
99.90% | ￥80.00 |
5 | - | - | - | - |
|
S80519-10mg |
99.90% | ￥130.00 |
>10 | - | - | - | - |
|
S80519-25mg |
99.90% | ￥270.00 |
1 | - | - | - | - |
|
S80519-50mg |
99.90% | ￥420.00 |
6 | - | - | - | - |
|
S80519-100mg |
≥99% | ￥720.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: < 25 nM (NAMPT);Apoptosis;NAMPT | ||||||||||||||||||||
| 体内研究： | A 4-h iv infusion of NA (120 mg/kg of body weight) did not adversely affect the antitumor activity of a 24-h iv infusion of CHS-828 (GMX1778) at a dose of 150 mg/kg or 650 mg/kg in the NAPRT1-deficient xenograft experiments. CHS-828 (GMX1778) at 650 mg/kg is above the maximum tolerated dose. The administration of NA as a 4-h iv infusion immediately following treatment with 750 mg/kg CHS-828 (GMX1778) reduced the mortality associated with toxic doses of GMX1777 | ||||||||||||||||||||
| 参考文献： | 1. Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29(21):5872-88. 2. Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 39 mg/mL (104.88 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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