| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80528-1mg促销 |
99.86% | ￥205.00 ￥198.00 |
5 | 2 | - | - | - |
|
S80528-5mg促销 |
99.86% | ￥556.00 ￥555.00 |
5 | - | 2 | - | - |
|
S80528-10mg促销 |
99.86% | ￥779.00 ￥778.00 |
7 | - | - | - | - |
|
S80528-50mg买3赠1 |
99.86% | ￥2700.00 |
4 | 1 | - | - | - |
|
S80528-100mg买3赠1 |
99.86% | ￥3790.00 |
6 | - | - | - | - |
|
S80528-250mg |
99.86% | ￥6620.00 |
4 | - | - | - | - |
|
S80528-500mg |
99.86% | ￥10300.00 |
3 | - | - | - | - |
|
S80528-1g |
99.86% | ￥18000.00 |
1 | - | - | - | - |
|
| 产品描述： | Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats | ||||||||||||||||||||
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| 靶点： | Kb: 0.84 nM (mAChR);AChR | ||||||||||||||||||||
| 体内研究： | Desfesoterodine (PNU-200577; 5-Hydroxymethyl Tolterodine; 0.1 and 1 mg/kg; IV) significantly increases bladder compliance after moderate and high doses. In vivo, Desfesoterodine is significantly more potent at suppressing acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50=15 and 40 nmol/kg, respectively) | ||||||||||||||||||||
| 参考文献： | 1. Nilvebrant L, Gillberg PG, Sparf B. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol. 1997 Oct;81(4):169-72. 2. Fullhase, Claudius; Soler, Roberto; Gratzke, Christian et al. Spinal effects of the fesoterodine metabolite 5-hydroxymethyl tolterodine and/or doxazosin in rats with or without partial urethral obstruction. Journal of Urology (New York, NY, United States) 3. B Malhotra, et al. The Design and Development of Fesoterodine as a Prodrug of 5-hydroxymethyl Tolterodine (5-HMT), the Active Metabolite of Tolterodine. Curr Med Chem. 2009;16(33):4481-9. 4. Naoki Aizawa, et al. Selective Inhibitory Effect of Imidafenacin and 5-hydroxymethyl Tolterodine on Capsaicin Sensitive C Fibers of the Primary Bladder Mechanosensitive Afferent Nerves in the Rat. J Urol. 2015 Apr;193(4):1423-32. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京