货号	规格	价格	上海	北京	珠海	重庆	武汉
S80532-1mg买3赠1	98.90%	￥272.00 S80532-1mg ￥272.00 现货（买3赠1）	4 4	-	-	-	-
S80532-2mg买3赠1	98.90%	￥360.00 S80532-2mg ￥360.00 现货（买3赠1）	5 5	-	-	-	-
S80532-5mg买3赠1	98.90%	￥680.00 S80532-5mg ￥680.00 现货（买3赠1）	6 6	-	-	-	-
S80532-10mg买3赠1	98.90%	￥1190.00 S80532-10mg ￥1190.00 现货（买3赠1）	6 6	-	-	-	-
S80532-25mg买3赠1	98.90%	￥2270.00 S80532-25mg ￥2270.00 现货（买3赠1）	3 3	-	-	-	-
S80532-50mg买3赠1	≥98%	￥3410.00 S80532-50mg ￥3410.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor

靶点：

IC50: 2.92±0.22 (Notch), 2.64±0.30 (APPL) nM;Gamma-secretase

体内研究：

DBZ blocks activated Notch1 signaling in abdominal aortic aneurysm (AAA) tissue from both Ang II-infused Apo E-/- mice and human undergoing AAA repair. DBZ markedly prevents Ang II-stimulated accumulation of macrophages and CD4+ T cells, and ERK-mediated angiogenesis, simultaneously reverses Th2 response, in vivo. Administration of DBZ markedly attenuates renal fibrosis and expression of fibrotic markers, including collagen 1α1/3α1, fibronectin, and α-smoothmuscle actin. DBZ significantly inhibits ureteral obstruction -induced expression of transforming growth factor (TGF)- β, phosphorylated Smad 2, and Smad 3

参考文献：

1. Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74. 2. Fuwa H, et al. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol. 2007 Jun 15;2(6):408-18. 3. Zheng YH, et al. Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms. PLoS One. 2013 Dec 16;8(12):e83310. 4. Xiao Z, et al. The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. Int J Biochem Cell Biol. 2014 Oct;55:65-71.

溶解性：

DMSO : 50 mg/mL (107.88 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.158 ml	10.788 ml	21.576 ml
5 mM	0.432 ml	2.158 ml	4.315 ml
10 mM	0.216 ml	1.079 ml	2.158 ml
50 mM	0.043 ml	0.216 ml	0.432 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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