Dabigatran (BIBR 953)

97.90%

Dabigatran (BIBR 953)

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品牌：源叶(MedMol)

产品编号：S80537 一键复制产品信息

CAS号：211914-51-1

分子式：C₂₅H₂₅N₇O₃

分子量：471.51

别名：达比加群;N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并[D]咪唑-5-基]羰基]-N-吡啶-2-基-BETA-丙氨酸

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80537-5mg	97.90%	￥480.00 S80537-5mg ￥480.00 现货	1681 >10	-	-	-	-
S80537-10mg	97.90%	￥680.00 S80537-10mg ￥680.00 现货	844 0 >10	-	-	-	-
S80537-50mg	97.90%	￥1920.00 S80537-50mg ￥1920.00 现货	170 >10	-	-	-	-
S80537-100mg	97.90%	￥3200.00 S80537-100mg ￥3200.00 现货	87 >10	-	-	-	-
S80537-250mg	97.90%	￥5760.00 S80537-250mg ￥5760.00 现货	35 >10	-	-	-	-

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产品介绍参考文献(2篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)

靶点：

Ki: 4.5 nM (thrombin);Thrombin

体内研究：

Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model

参考文献：

1. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62. 2. Hauel NH, et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem. 2002 Apr 25;45(9):1757-66. 3. Wienen W, et al. Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats. Thromb Haemost. 2007 Aug;98(2):333-8.

溶解性：

0.1 M HCL : 12.5 mg/mL (26.51 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) DMSO : < 1 mg/mL (insoluble or slightly soluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.121 ml	10.604 ml	21.208 ml
5 mM	0.424 ml	2.121 ml	4.242 ml
10 mM	0.212 ml	1.06 ml	2.121 ml
50 mM	0.042 ml	0.212 ml	0.424 ml