Sincalide

99.11%

Sincalide

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品牌：源叶(MedMol)

产品编号：S80567 一键复制产品信息

CAS号：25126-32-3

分子式：C₄₉H₆₂N₁₀O₁₆S₃

分子量：1143.27

别名：辛卡利特;氯缩胆囊素八肽;醋酸辛卡利特;H-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2;H-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 AMMONIUM SALT;CHOLECYSTOKININ [TYR(SO3H)27]-FRAGMENT 26-33 AMIDE;CHOLECYSTOKININ, OCTAPEPTID

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80567-1mg	99.11%	￥290.00 S80567-1mg ￥290.00 现货	3 4 3	2	2	-	-
S80567-5mg	≥99%	￥790.00 S80567-5mg ￥790.00 2-3天	0 0 货期：2-3天	-	-	-	-
S80567-25mg	99.11%	￥2500.00 S80567-25mg ￥2500.00 现货	2 2	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Sincalide (Cholecystokinin octapeptide, CCK‐8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. CCK‐8 can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK

靶点：

Cholecystokinin Receptor;Apoptosis;PI3KAkt

体内研究：

Sincalide (Cholecystokinin octapeptide, CCK‐8) (i.p.; 50 μg/kg/d; for 4 weeks) alleviates fibrosis in the noninfarcted regions and delay the left ventricular remodeling and the progress of heart failure in a MI rat model

参考文献：

1. Maher KA et al. Kinevac (sincalide for injection)/Squibb Diagnostics. Gastroenterol Nurs. 1991 Oct;14(2):98-100. 2. Ziessman HA. Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues. J Nucl Med Technol. 2019 Sep;47(3):210-212. 3. Can Wang, et al. Protective effect of cholecystokinin octapeptide on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells. J Cell Biochem. 2020 Jul;121(7):3560-3569. 4. Can Wang, et al. Cholecystokinin octapeptide reduces myocardial fibrosis and improves cardiac remodeling in post myocardial infarction rats. Int J Biochem Cell Biol. 2020 Aug;125:105793.

溶解性：

DMF : 50 mg/mL (43.73 mM; Need ultrasonic) H2O : 0.1 mg/mL (0.09 mM; Need ultrasonic and warming)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.875 ml	4.373 ml	8.747 ml
5 mM	0.175 ml	0.875 ml	1.749 ml
10 mM	0.087 ml	0.437 ml	0.875 ml
50 mM	0.017 ml	0.087 ml	0.175 ml