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CHIR-98014,GSK-3抑制剂

    
98%

CHIR-98014

源叶(MedMol)
S80569 一键复制产品信息
252935-94-7
C20H17Cl2N9O2
486.31
N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)pyrimidin-2-ylamino)ethyl)-5-nitropyridine-2,6-diamine;CHIR-98014
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S80569-5mg促销
98%

¥736.00 ¥662.00

10 3 2 - -
S80569-10mg促销
98%

¥1290.00 ¥1160.00

货期:3-5天 - - - -
S80569-25mg促销
98%

¥2590.00 ¥2330.00

10 3 - - -
S80569-50mg促销
98%

¥4350.00 ¥3920.00

货期:3-5天 - - - -
S80569-100mg促销
98%

¥6790.00 ¥6110.00

货期:3-5天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: CHIR-98014 is a potent, cell-permeable GSK-3 inhibitor with IC50s of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; it shows less potent activities against cdc2 and erk2.
靶点: GSK-3β:0.58 nM (IC50);GSK-3α:0.65 nM (IC50);cdc2:3700 nM (IC50);FGFR;GSK-3;Src;S6Kinase
体内研究: CHIR 98014 (30 mg/kg, i.p.) exhibits a significant reduction in fasting hyperglycemia within 4 h of treatment and shows improved glucose disposal during an ipGTT in markedly diabetic and insulin-resistant db/db mice
参考文献: 1. Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. 2. Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes. 2014 Apr 29;7:273. 3. Zajkowski T, et al. Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2228-39.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.056 ml 10.282 ml 20.563 ml
5 mM 0.411 ml 2.056 ml 4.113 ml
10 mM 0.206 ml 1.028 ml 2.056 ml
50 mM 0.041 ml 0.206 ml 0.411 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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