| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80569-5mg促销 |
98% | ￥736.00 ￥662.00 |
10 | 3 | 2 | - | - |
|
S80569-10mg促销 |
98% | ￥1290.00 ￥1160.00 |
货期：3-5天 | - | - | - | - |
|
S80569-25mg促销 |
98% | ￥2590.00 ￥2330.00 |
10 | 3 | - | - | - |
|
S80569-50mg促销 |
98% | ￥4350.00 ￥3920.00 |
货期：3-5天 | - | - | - | - |
|
S80569-100mg促销 |
98% | ￥6790.00 ￥6110.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | CHIR-98014 is a potent, cell-permeable GSK-3 inhibitor with IC50s of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; it shows less potent activities against cdc2 and erk2. | ||||||||||||||||||||
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| 靶点： | GSK-3β:0.58 nM (IC50);GSK-3α:0.65 nM (IC50);cdc2:3700 nM (IC50);FGFR;GSK-3;Src;S6Kinase | ||||||||||||||||||||
| 体内研究： | CHIR 98014 (30 mg/kg, i.p.) exhibits a significant reduction in fasting hyperglycemia within 4 h of treatment and shows improved glucose disposal during an ipGTT in markedly diabetic and insulin-resistant db/db mice | ||||||||||||||||||||
| 参考文献： | 1. Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. 2. Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes. 2014 Apr 29;7:273. 3. Zajkowski T, et al. Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2228-39. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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