| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80598-1mg买3赠1 |
99.40% | ￥784.00 |
8 | - | - | - | - |
|
S80598-2mg促销 |
99.40% | ￥1440.00 ￥1150.00 |
4 | - | - | - | - |
|
S80598-5mg促销 |
99.40% | ￥2800.00 ￥2240.00 |
4 | - | - | - | - |
|
S80598-10mg促销 |
99.40% | ￥5500.00 ￥4400.00 |
4 | - | - | - | - |
|
| 产品描述： | L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers | ||||||||||||||||||||
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| 靶点： | γ-secretase；Apoptosis;Apoptosis;Gamma-secretase | ||||||||||||||||||||
| 体内研究： | L-685458 (percutaneous administration; 5 mg/kg; 2 weeks) has antitumor effects in mouse hepatoma models. L-685458 inhibits EpCAM production except in necrotic areas. And HES1 staining is also diminished in the nucleus | ||||||||||||||||||||
| 参考文献： | 1. Shearman, M.S., Beher, D., Clarke, E.E., Lewis, H.D., Harrison, T., Hunt, P., 2. Guanghui Yang, et al. Structural basis of γ-secretase inhibition and modulation by small molecule drugs. Cell. 2021 Jan 21;184(2):521-533.e14. 3. Jonas Sjölund, et al. Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest. 2008 Jan;118(1):217-28. 4. Kazunori Kawaguchi, et al. Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer. Am J Pathol. 2016 Aug;186(8):2055-2067. | ||||||||||||||||||||
| 溶解性： | DMSO : 83.3 mg/mL (123.80 mM; Need ultrasonic and warming) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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