| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80607-5mg买3赠1 |
99.70% | ￥200.00 |
>10 | 2 | 1 | - | - |
|
S80607-10mg买3赠1 |
99.70% | ￥300.00 |
>10 | - | - | - | - |
|
S80607-25mg买3赠1 |
99.70% | ￥500.00 |
>10 | 2 | - | - | - |
|
S80607-50mg买3赠1 |
99.70% | ￥700.00 |
>10 | - | - | - | - |
|
S80607-100mg买3赠1 |
99.70% | ￥1260.00 |
>10 | - | - | - | - |
|
S80607-200mg买3赠1 |
≥98% | ￥2200.00 |
3 | - | - | - | - |
|
S80607-500mg买3赠1 |
≥98% | ￥4600.00 |
1 | - | - | - | - |
|
| 产品描述： | SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways | ||||||||||||||||||||
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| 靶点： | ALK4：1 μM (IC50)；ALK5：0.75 μM (IC50)；ALK7：2 μM (IC50);ALK;TGF-beta/Smad | ||||||||||||||||||||
| 体内研究： | SB-431542 (subconjunctival; 0.5 and 2 mM; on days 1, 2, 3, and 7) inhibits scar formation after glaucoma filtration surgery in New Zealand rabbits | ||||||||||||||||||||
| 参考文献： | 1. Gareth J Inman, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002 Jul;62(1):65-74. 2. Sunil K Halder, et al. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia. 2005 May;7(5):509-21. 3. Yi-qin Xiao, et al. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1698-706. | ||||||||||||||||||||
| 溶解性： | DMSO : 250 mg/mL (650.38 mM; Need ultrasonic) Ethanol : 11.17 mg/mL (29.06 mM; Need ultrasonic and warming) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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