货号	规格	价格	上海	北京	珠海	重庆	武汉
S80614-1mg买3赠1	99.20%	￥200.00 S80614-1mg ￥200.00 现货（买3赠1）	1 1	-	-	-	-
S80614-5mg买3赠1	99.20%	￥392.00 S80614-5mg ￥392.00 现货（买3赠1）	6 6	-	-	-	-
S80614-10mg买3赠1	99.20%	￥550.00 S80614-10mg ￥550.00 现货（买3赠1）	2 2	-	-	-	-
S80614-50mg买3赠1	99.20%	￥1520.00 S80614-50mg ￥1520.00 现货（买3赠1）	1 1	-	-	-	-
S80614-100mg买3赠1	≥98%	￥2620.00 S80614-100mg ￥2620.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt

靶点：

Akt

体内研究：

SC79 treatment, even at much high dose (0.4 mg/g of body weight), does not induce any detectable changes in body weight, survival rate, appearance, and behavior in mice. SC79 (10 mg/kg, i.p.) Protects C57BL/6 mice from fas-induced fulminant hepatic failure. SC79 protects hepatocytes from TNFα-mediated apoptosis and mice from Gal/LPS-induced liver injury and damage.

参考文献：

1. Jo H, et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-10586. 2. So EY, et al. BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction. BMC Cancer. 2014 Jul 29;14:548 3. Liu X, et al. Activation of Akt by SC79 decreased cerebral infarct in early cerebral ischemia-reperfusion despite increased BBB disruption. Neurosci Lett. 2018 Aug 10;681:78-82. 4. Liu W, et al. A Novel AKT Activator, SC79, Prevents Acute Hepatic Failure Induced by Fas-Mediated Apoptosis of Hepatocytes. Am J Pathol. 2018 May;188(5):1171-1182. 5. Jing ZT, et al. AKT activator SC79 protects hepatocytes from TNF-α-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G387-G396.

溶解性：

DMSO : 100 mg/mL (274.14 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.741 ml	13.707 ml	27.414 ml
5 mM	0.548 ml	2.741 ml	5.483 ml
10 mM	0.274 ml	1.371 ml	2.741 ml
50 mM	0.055 ml	0.274 ml	0.548 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(6篇)

6. [IF=2.9] Lele Zhou, et al. "Tripchlorolide-induced reversible impairment of male fertility and the involvement of PI3K/Akt/mTOR signaling"TOXICOLOGY LETTERS, 2026 May;419:111872 5. [IF=4.7] Mengyuan Zhou et al."TNK2 promotes the EMT proliferation and invasion of esophageal squamous cell carcinoma by enhancing FOXO1 through the AKT pathway."INTERNATIONAL IMMUNOPHARMACOLOGY.2026 Jan;169:115939 4. [IF=3.9] Yijun Yang et al."IL4I1 overexpression protects against nonalcoholic fatty liver disease in part by inhibiting the AKT/FOXO1 pathway-mediated Th17 cell differentiation."JOURNAL OF BIOLOGICAL CHEMISTRY.2025 Sep;301:110560 3. [IF=3.9] Yijun Yang et al."IL4I1 overexpression protects against nonalcoholic fatty liver disease in part by inhibiting the AKT/FOXO1 pathway-mediated Th17 cell differentiation."JOURNAL OF BIOLOGICAL CHEMISTRY.2025 Sep;301:110560 2. [IF=4.8] Na Yang et al."Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway."Frontiers in Pharmacology.2025 May;16:

1. [IF=5.7] Jie Zhao et al."Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2024;XXXX(XXX):XXX-XXX

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

SC79

2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester

参考文献(6篇)

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)