| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80639-1mg买3赠1 |
99.70% | ￥102.00 |
9 | - | - | - | - |
|
S80639-5mg买3赠1 |
99.70% | ￥122.00 |
>10 | - | - | - | - |
|
S80639-10mg促销 |
99.70% | ￥200.00 ￥160.00 |
10 | - | - | - | - |
|
S80639-25mg促销 |
99.70% | ￥400.00 ￥320.00 |
9 | - | - | - | - |
|
S80639-50mg促销 |
99.70% | ￥750.00 ￥600.00 |
9 | - | - | - | - |
|
S80639-100mg促销 |
≥99% | ￥940.00 ￥752.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC50s of >100 μM. | ||||||||||||||||||||
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| 靶点： | GSK-3β:2 μM (IC50);GSK-3 | ||||||||||||||||||||
| 体内研究： | TDZD-8 (TDZD8, 1 or 2 mg/kg, i.p.) both reduces the induction of p-DARPP32 following chronic L-dopa treatment in parkinsonian animals. TDZD8 treatment of 21 days induces a significant reduction in PKA expression in rats with established dyskinesia. Moreover, TDZD8 reduces FosB mRNA level in the striatum and lowers the expression of PPEB mRNA to similar levels as in 6-OHDA-lesioned rats without treated with L-dopa. The decrease in dyskinesia induced by TDZD8 is overcome by dopamine rceptor-1 agonist | ||||||||||||||||||||
| 参考文献： | 1. Martinez A, et al. First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem. 2002 Mar 14;45(6):1292-9. 2. Xie CL, et al. Inhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. Sci Rep. 2016 Mar 21;6:23527.3. Sun A, et al. GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells. Prostate. 2016 Feb;76(2):172-83. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 100 mg/mL (449.92 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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