| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80641-1mg买3赠1 |
99.70% | ￥140.00 |
9 | - | - | - | - |
|
S80641-2mg买3赠1 |
99.70% | ￥240.00 |
9 | - | - | - | - |
|
S80641-5mg买3赠1 |
99.70% | ￥330.00 |
7 | - | - | - | - |
|
S80641-10mg买3赠1 |
99.70% | ￥590.00 |
5 | - | - | - | - |
|
S80641-25mg促销 |
99.70% | ￥1370.00 ￥1090.00 |
4 | - | - | - | - |
|
S80641-50mg促销 |
≥99% | ￥2380.00 ￥1900.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current | ||||||||||||||||||||
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| 靶点： | CFTR;CFTR;Autophagy | ||||||||||||||||||||
| 体内研究： | GlyH-101 (2.5 µg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse | ||||||||||||||||||||
| 参考文献： | 1. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124(2):125-37. 2. Kelly M, et al. Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther. 2010 Apr;333(1):60-9. 3. Barman PP, et al. Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101. Biochem Biophys Res Commun. 2011 Apr 29;408(1):12-7. 4. Melis N, et al. Revisiting CFTR inhibition: a comparative study of CFTRinh -172 and GlyH-101 inhibitors. Br J Pharmacol. 2014 Aug;171(15):3716-27. 5. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124(2):125-37. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 58 mg/mL (117.61 mM) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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