| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80643-2mg买3赠1 |
99.99% | ￥232.00 ￥200.00 |
3 | - | - | - | - |
|
S80643-5mg买3赠1 |
≥98% | ￥360.00 ￥320.00 |
货期：2-3天 | - | - | - | - |
|
S80643-10mg买3赠1 |
99.99% | ￥640.00 ￥570.00 |
4 | - | - | - | - |
|
S80643-25mg买3赠1 |
99.99% | ￥1560.00 ￥1400.00 |
7 | - | - | - | - |
|
S80643-50mg买3赠1 |
99.99% | ￥2480.00 ￥2230.00 |
1 | - | - | - | - |
|
S80643-100mg买3赠1 |
≥98% | ￥4560.00 ￥4100.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | C646 is a selective and competitive histone acetyltransferase p300 inhibitor with Ki of 400 nM, and is less potent for other acetyltransferases | ||||||||||||||||||||
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| 靶点： | Ki: 400 nM (histone acetyltransferase p300);Apoptosis;EpigeneticReaderDomain;HistoneAcetyltransferase;Autophagy | ||||||||||||||||||||
| 体内研究： | Suppression of P300 by c646 (intraperitoneally injected, 30 nmol/g/d for 2 weeks) dramatically reduces the level of blood glucose in db/db mice | ||||||||||||||||||||
| 参考文献： | 1. Bowers EM, et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28;17(5):471-82. 2. Oike T, et al. C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe. Radiother Oncol. 2014 May;111(2):222-7. 3. Zheng WW, et al. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cells. 2014 Aug;32(8):2278-89. 4. Zhen Fan, et al. Type 2 diabetes-induced overactivation of P300 contributes to skeletal muscle atrophy by inhibiting autophagic flux. Life Sci. 2020 Aug 10;258:118243. | ||||||||||||||||||||
| 溶解性： | DMSO : 16.67 mg/mL (37.43 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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