货号	规格	价格	上海	北京	珠海	重庆	武汉
S80647-5mg买3赠1	≥98%	￥300.00 S80647-5mg ￥300.00 现货（买3赠1）	100 >10	-	-	-	-
S80647-10mg买3赠1	≥98%	￥520.00 S80647-10mg ￥520.00 现货（买3赠1）	50 >10	-	-	-	-
S80647-25mg买3赠1	≥98%	￥1150.00 S80647-25mg ￥1150.00 现货（买3赠1）	20 >10	-	-	-	-
S80647-50mg买3赠1	≥98%	￥1950.00 S80647-50mg ￥1950.00 现货（买3赠1）	10 10	-	-	-	-

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产品描述：

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.

靶点：

Apoptosis;Aurora Kinase;MEK;Src;Apoptosis;MEK;Src;AuroraKinase

细胞实验：

Cell number is evaluated by crystal violet staining. In brief, cells in 96-well plates are fixed with 1% glutaraldehyde. Then cells are stained with 0.1% crystal violet. The unbound dye is removed by washing with water. Bound crystal violet is solubilized with 0.2% Triton X-100. Light extinction which increases linearly with the cell number is analyzed at 570 nm using an ELISA reader.(Only for Reference)

参考文献：

1. Ditchfield C, et al. J Cell Biol. 2003, 161(2), 267-280. 2. Zhang L, et al. J Obstet Gynaecol Res. 2011, 37(6), 591-600. 3. Teperek-Tkacz M, et al. Cell Cycle. 2010, 9(23), 4674-4687. 4. Georgieva I, et al. Neuroendocrinology. 2010, 91(2), 121-130.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.947 ml	9.735 ml	19.471 ml
5 mM	0.389 ml	1.947 ml	3.894 ml
10 mM	0.195 ml	0.974 ml	1.947 ml
50 mM	0.039 ml	0.195 ml	0.389 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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