货号	规格	价格	上海	北京	珠海	重庆	武汉
S80663-5mg促销	≥98%	￥168.00 ￥150.00 S80663-5mg ￥150.00 现货	10 10	-	-	-	-
S80663-10mg促销	≥98%	￥279.00 ￥250.00 S80663-10mg ￥250.00 现货	10 10	-	-	-	-
S80663-50mg促销	≥98%	￥1040.00 ￥936.00 S80663-50mg ￥936.00 现货	10 10	-	-	-	-
S80663-100mg促销	≥98%	￥1530.00 ￥1370.00 S80663-100mg ￥1370.00 现货	10 10	-	-	-	-
S80663-250mg促销	≥98%	￥2120.00 ￥1910.00 S80663-250mg ￥1910.00 现货	7 7	-	-	-	-
S80663-1g促销	≥98%	￥5320.00 ￥4780.00 S80663-1g ￥4780.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2, CDK7, and CDK9 with IC50s of 38 nM, 62 nM and 4 nM, respectively. SNS-032 has antitumor effect

靶点：

CDK9:4 nM (IC50);CDK2:38 nM (IC50);CDK7:62 nM (IC50);CDK1:480 nM (IC50);CDK4:925 nM (IC50);Apoptosis;GSK-3;CDK

体内研究：

SNS-032 (15 mg/kg, i.p.) inhibits both xenografted BaF3-T674I cells and KBM5-T315I cells in vivo. SNS-032 abrogates the growth of tumors transplanted in nude mice with downregulation of T674I PDGFRα and T315I-Bcr-Abl

参考文献：

1. Chen R, et al. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45. 2. Ali MA, et al. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia. 2007 May;9(5):370-81. 3. Conroy A, et al. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother Pharmacol. 2009 Sep;64(4):723-32. 4. Wu Y, et al. Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.Clin Cancer Res. 2012 Apr 1;18(7):1966-78. Epub 2012 Mar 23. 5. Walsby E, et al. The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells. Leukemia. 2011 Mar;25(3):411-9. Epub 2011 Jan 7.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.628 ml	13.14 ml	26.279 ml
5 mM	0.526 ml	2.628 ml	5.256 ml
10 mM	0.263 ml	1.314 ml	2.628 ml
50 mM	0.053 ml	0.263 ml	0.526 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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