| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80667-2mg买3赠1 |
98.70% | ￥150.00 |
7 | - | - | - | - |
|
S80667-5mg买3赠1 |
98.70% | ￥180.00 |
8 | - | - | - | - |
|
S80667-10mg买3赠1 |
98.70% | ￥290.00 |
6 | - | - | - | - |
|
S80667-25mg促销 |
98.70% | ￥590.00 ￥472.00 |
6 | - | - | - | - |
|
S80667-50mg促销 |
98.70% | ￥910.00 ￥728.00 |
4 | - | - | - | - |
|
S80667-100mg促销 |
≥98% | ￥1400.00 ￥1120.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | HSV-1:0.02 μM (IC50);HSV-2:0.02 μM (IC50);DNA/RNASynthesis;HSV | ||||||||||||||||||||
| 体内研究： | Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase-primase enzyme complex. Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis. Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS. | ||||||||||||||||||||
| 参考文献： | 1. Ligat G, et al. Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-PrimaseComplex. Front Microbiol. 2018 Oct 23;9:2483. 2. Wald A, et al. Helicase-primase inhibitor Pritelivir for HSV-2 infection. N Engl J Med. 2014 Jan 16;370(3):201-10. 3. Quenelle DC, et al. Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. Antiviral Res. 2018 Jan;149:1-6. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 33 mg/mL (81.99 mM) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京