货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S80671-100mg促销	99.92%	￥149.00 ￥134.00 S80671-100mg ￥134.00 现货	8 8	4	4	3	-
S80671-500mg促销	≥98%(HPLC)	￥742.00 ￥666.00 S80671-500mg ￥666.00 现货	7 7	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties

靶点：

DNA Alkylator/Crosslinker;Apoptosis; DNAAlkylator/Crosslinker; DNA/RNASynthesis

体内研究：

Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model

参考文献：

1. Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. 2. Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. 3. Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.533 ml	12.667 ml	25.334 ml
5 mM	0.507 ml	2.533 ml	5.067 ml
10 mM	0.253 ml	1.267 ml	2.533 ml
50 mM	0.051 ml	0.253 ml	0.507 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Bendamustine hydrochloride hydrate